Piedmont olive oils: Compositional characterization and discrimination from oils from other regions

Piedmont olive oils collected in 2010 were characterized, for the first time, in terms of their fatty acid profile using GC and ¹H NMR and compared to other oils from five Italian regions. Applying NMR spectroscopy on the olive oil samples, without manipulation, it is possible to calculate the proportion of the different acyl groups in the oil samples. As the area of the signals is proportional to the number of each type of proton in the sample, saturated, monounsaturated (oleic acid) and polyunsaturated (linoleic and linolenic acids) fatty acids were determined. All analyzed samples can be categorized as virgin olive oil extra quality according to the oleic/linoleic ratio. Based on a preliminary geographical investigation, olive oils produced in the North of Italy show a good separation from those from Central and Southern regions. Practical applications : Oil characterization of new products is the basis for further nutritional and food technological investigations and the quality of edible oils is of great concern especially for products available on the market. The two adopted techniques show a remarkable agreement in the evaluation of fatty acid composition of oil samples. Also, this research, by means of ¹H NMR, provides information on geographical origin of the olive oils of Northern Italian regions with respect to Central and Southern regions.     

The Patient Visits Program: a strategy to highlight patient satisfaction and refocus organizational culture

BACKGROUND: Seeking patient input may improve patients' perceptions of the quality of care and provide managers with helpful information for strategic decision making. In addition, the involvement of senior hospital leadership is critical to successful implementation of quality improvement initiatives and illustrates an organization's commitment to enhancing quality from the top down. IMPLEMENTING THE PVP: Senior management's Patient Visits Program (PVP) at Tufts-New England Medical Center is a structured, ongoing initiative in which senior clinicians are paired with nonclinician administrators. During an initial evaluation period (Aug 1999-Feb 2001), PVP teams visited with patients and their families on a monthly basis to talk to them about their experiences. Patient suggestions were then evaluated and acted on. DISCUSSION: The PVP has been beneficial for patients and for the hospital team members--clinicians and nonclinicians alike--who participated in the patient interviews. The PVP may serve as a mechanism to enhance organizational awareness of the importance of patient satisfaction. The program provides opportunities for immediate service recovery, and faster, broader-reaching responses to quality complaints due to the multispecialty nature of the PVP teams. In addition, based on early available data, the PVP shows promise as an interventional strategy to improve patient satisfaction scores. CONCLUSIONS: A structured, ongoing program such as the PVP is an effective strategy to highlight the value of patient satisfaction, refocus organizational culture, and generate specific suggestions for improving the quality of patient care.     

Usability,user experience and mental workload in a mobile Augmented Reality application for digital storytelling in cultural heritage

Virtual Reality - Augmented Reality (AR) has become an increasingly used technology to support and enhance the enjoyment of cultural heritage. Particularly relevant is its importance for...     

Mutual information function assesses autonomic information flow of heart rate dynamics at different time scales

The autonomic information flow (AIF) represents the complex communication within the Autonomic Nervous System (ANS). It can be assessed by the mutual information function (MIF) of heart rate fluctuations (HRF). The complexity of HRF is based on several interacting physiological mechanisms operating at different time scales. Therefore one prominent time scale for HRF complexity analysis is not given a priori. The MIF reflects the information flow at different time scales. This approach is defined and evaluated in the present paper. In order to aggregate relevant physiological time scales, the MIF of HRF obtained from eight adult Lewis rats during the awake state, under general anesthesia, with additional vagotomy, and additional betal-adrenergic blockade are investigated. Physiologically relevant measures of the MIF were assessed with regard to the discrimination of these states. A simulation study of a periodically excited pendulum is performed to clarify the influence of the time scale of MIF in comparison to the Kolmogorov Sinai entropy (KSE) of that well defined system. The general relevance of the presented AIF approach was confirmed by comparing mutual information, approximate entropy, and sample entropy at their respective time scales.     

Acid-Sphingomyelinase Triggered Fluorescently Labeled Sphingomyelin Containing Liposomes in Tumor Diagnosis after Radiation-Induced Stress

In liposomal delivery, a big question is how to release the loaded material into the correct place. Here, we will test the targeting and release abilities of our sphingomyelin-consisting liposome. A change in release parameters can be observed when sphingomyelin-containing liposome is treated with sphingomyelinase enzyme. Sphingomyelinase is known to be endogenously released from the different cells in stress situations. We assume the effective enzyme treatment will weaken the liposome making it also leakier. To test the release abilities of the SM-liposome, we developed several fluorescence-based experiments. In in vitro studies, we used molecular quenching to study the sphingomyelinase enzyme-based release from the liposomes. We could show that the enzyme treatment releases loaded fluorescent markers from sphingomyelin-containing liposomes. Moreover, the release correlated with used enzymatic activities. We studied whether the stress-related enzyme expression is increased if the cells are treated with radiation as a stress inducer. It appeared that the radiation caused increased enzymatic activity. We studied our liposomes’ biodistribution in the animal tumor model when the tumor was under radiation stress. Increased targeting of the fluorescent marker loaded to our liposomes could be found on the site of cancer. The liposomal targeting in vivo could be improved by radiation. Based on our studies, we propose sphingomyelin-containing liposomes can be used as a controlled release system sensitive to cell stress.     

Perfluorinated oxygen- and sulfur-containing compounds as extractants for gold(III)

A series of highly fluorinated compounds of the type {CF₃(CF₂)₅CH₂CH₂}₃P=O, [{CF₃(CF₂)₅CH₂CH₂}₂P(E)CH₂CH₂P(E){CH₂CH₂(CF₂)₅CF₃}] and {CF₃(CF₂)₅CH₂CH₂}₂C=E (E = O or S) have been examined for their ability to extract gold(III) from aqueous solutions. The phosphine oxides have been studied under liquid–liquid extraction conditions from water into perfluorohexane and found to give poor distribution ratios. The bidentate phosphine oxide, ketone and thioketone were studied under solid–liquid extraction conditions and were substantially better with extraction of up to 80% of Au(III). In addition, the crystal structure of {CF₃(CF₂)₅CH₂CH₂}₃P=O has been determined.     

Minimum surcharge load of URM walls under flexure and axial force / Mindestauflast bei Biegung mit Normalkraft

This paper suggests a detailed parametric study, which has been drawn up in connection with the question of the necessity of verification of masonry wall by a minimum vertical load subject to bending and normal force by the author and his team [7]. It assumes the actual eccentricities from supporting due floors and takes into account the second order theory in middle of wall according to DIN EN 1996‐1‐1 or the German NA. In some cases, the model is derived for very high wind loads to its limits. Using the arch model which is introduced in DIN EN 1996‐1‐1 and may be applied by NA, is helpful and effective. This method may provide higher capacity rather than for example, with the bar or plate model. In this article the verification by means of the arch model will be presented and discussed. It is also shown that, forming an arch opposing to the horizontal wind load and low vertical loads may not come to a stability failure.